March 5th 2025
BLP-003, currently being evaluated for treatment-resistant depression and alcohol use disorder, today announced their global phase 2b clinical trial has completed patient enrollment.
Consequences of Population Drift
March 23rd 2011Writers of diagnostic criteria should consider their work and all its implications. What about adding a new disorder? What might that do to epidemiological capture? Depending on the characteristics of the diagnostic criteria set, many possibilities exist.
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Does Research Support “Craving” as a Core Symptom of Substance Use Disorders in DSM-5?
January 11th 2011Recently, the Substance Use Disorder Work group of the DSM-5 announced the inclusion of “craving” in the diagnostic criteria for all substance use disorders despite its lack of empirical support from the very analyses conducted by that Workgroup. In addition, no detailed literature review supports the decision to make “craving” a core symptom of Substance Use Disorder syndromes.
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DSM5 Task Force: Do Not Go to the Mass Media-Do Your Homework
December 1st 2010As I was driving to work on February 10, 2010, I listened to the National Public Radio host Melissa Block talking about how children labeled “bipolar” may get a new diagnosis. I was shocked that the chair of one of the DSM5 work groups, David Shaffer, MD, would discuss a controversial diagnostic topic with the media.
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Science Versus Pragmatism in the DSM: Finding A Middle Ground
November 18th 2010The DSM does and must involve both science and pragmatism. It must use the science that is available, but it must also make countless judgment calls that are not grounded in solid empirical evidence-and surely it makes sense to consider practical consequences in doing the latter.
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Biological Consequences and Transgenerational Impact of Violence and Abuse
November 17th 2010Every year, more than 1 million children are exposed to sexual or physical abuse or neglect in the US. The research summarized here clearly demonstrates that exposure to stress before adulthood can result in persistent effects on both mental and physical health.
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Reasons Patients Doubt Medication-Resistant Delusions in Schizophrenia
October 30th 2010Our study suggests that most delusional patients, even those with high positive symptom scores, may have at least 1 RFD that precedes a clinical intervention specifically directed toward encouraging doubt. These preexisting “islands of doubt” may offer a useful foothold to begin the CBT process.
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Grief and Depression Redux: Response to Dr Frances’s “Compromise”
September 28th 2010Clearly, we all share the goals of respecting-not “medicalizing”-ordinary grief; as well as recognizing and treating clinically significant depression. We differ with Dr Frances in how to achieve these goals, while remaining faithful to the best available scientific data.
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Talking to Adolescents May Ward Off Future Violent Behavior and Alcohol Use
September 4th 2010A 3-year study involving over 3,000 patients used motivational interviewing to counsel adolescents about staying away from potentially violent and alcohol-related situations. It was found that these brief sessions “reduced by half the chances that teenagers would experience peer violence or problems due to drinking.”
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Trapped Under the Earth: How Will the Chilean Miners Fare?
September 1st 2010There are very real concerns about the miners’ mental well-being. Chile’s Health Minister reported that five of the men were not eating properly and refused to be filmed. In the meantime, a team of nutritionists and psychologists have been assembled to monitor their physical and mental states.
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If I Am Not For Myself: The Trials and the Triumphs of the Transgendered
September 1st 2010Just imagine. If you are not a transgender individual, what must it feel like to always think, as far back as you may remember, that you should have the body of the opposite gender? That you were “born in the wrong body”.
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