March 5th 2025
BLP-003, currently being evaluated for treatment-resistant depression and alcohol use disorder, today announced their global phase 2b clinical trial has completed patient enrollment.
Are the Media and the Public Still Missing the Clues?
It is our responsibility as psychiatrists to educate the media and the public in general.
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For prescribing psychiatrists who want to offer treatment alternatives to patients who prefer to avoid medication, the evidence is clear that psychotherapy is an effective choice. Even in cases in which medication is accepted, the evidence suggests that psychotherapy may significantly improve patient outcomes.
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DSM-5 Stubbornly Circles The Wagons Against Opposition From The Field
August 10th 2011Bob Spitzer was prophetic 4 years ago when he warned that the closed DSM-5 process would lead to a flawed DSM-5 product. He advised the DSM-5 leadership to end its secrecy-- that a lack of openness would inevitably would lead to bad decisions not amenable to self-correction.
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Scandalous Off Label Use Of Antipsychotics: Another Warning For DSM-5
August 6th 2011I never would have entered the DSM-5 controversy were it not for two of its proposals that risk furthering the already frightening overuse of antipsychotic medication, particularly in children and teenagers.
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Returning Veterans With Addictions
July 15th 2011Members of the military returning from combat operations have high rates of substance abuse. They also often exhibit a co-occurring triad of posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and pain, which complicates the problems with substance abuse.
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Traumatic Brain Injury Among Veterans Returning From Afghanistan and Iraq
July 14th 2011This article addresses the epidemiology, diagnosis, and treatment of mild TBI among combat veterans, with a particular focus on blast injury and the presence of comorbid posttraumatic stress disorder (PTSD).
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Drs McGlashan and Woods Respond to Dr Feinberg
June 29th 2011Dr Feinberg takes exception to much of what we wrote, or what he thinks we wrote, in our article “Early Antecedents and Detection in Schizophrenia”. We will do our best to reply to his criticisms of what we did write and try to point out where he is shadowboxing at issues that he has created but that we do not hold or endorse.
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Emil Kraepelin on Cultural and Ethnic Factors in Mental Illness
June 23rd 2011In the sixth edition of his famous 2-volume textbook Psychiatrie, which appeared in 1899, Emil Kraepelin introduced the by now well-known distinction between dementia praecox (soon to be called schizophrenia) and manic-depressive illness.
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Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence
June 9th 2011The COMBINE study was only one trial designed by academics to maximize internal scientific validity. It excluded individuals with other significant psychiatric and medical illnesses (more often the rule than the exception in some clinical settings)-individuals deemed too severely ill or who needed hospitalization.
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Introduction: Comorbidity, Cognition, and Pharmacotherapies
June 9th 2011In this Special Report, Helen M. Pettinati, PhD, and William D. Dundon, PhD, discuss prevalence, assessment, clinical features, and treatment issues with respect to individuals with co-occurring major depression and alcohol dependence.
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Australia's Reckless Experiment In Early Intervention
June 8th 2011A charismatic psychiatrist, Patrick McGorry has recently gained heroic status. First he was chosen to be Australia's Man Of The Year. Now, he has convinced the Australian government to spend more than $400 million over 5 years to fund his plan for a nationwide system of Early Psychosis Prevention and Intervention Centres.
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Self-medication for Anxiety Increases Risk for Substance Use Disorders
May 25th 2011Patients with anxiety disorders who self-medicate with alcohol or drugs may be increasing their risk for developing incident substance use disorders, according to a study presented at the American Psychiatric Association’s recent annual meeting.
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Nearly Half of Kids in Inpatient Psychiatric Program Receive Antipsychotics
May 24th 2011In a decade-long study of antipsychotic prescribing for hospitalized children and adolescents, researchers found that antipsychotics were used in 44.3% of patients and were often prescribed for behavioral disorders, PTSD, and other anxiety disorders as well as psychotic disorders.
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Conference Report: Daniel Paul Schreber Centenary–200 Years of Sonnenstein
May 17th 2011A report on the first international conference on Daniel Paul Schreber: "No comparison can be drawn between the sublime suffering of 1 individual-a man who, even in his madness, remained a member of Germany’s elite-and the horrors that would be perpetrated in that institution in the years to come..."
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Does MDMA Have a Role in Clinical Psychiatry?
May 7th 2011Like every drug or technology that has therapeutic value, MDMA (3,4-methylenedioxymethamphetamine) has potential risks and benefits. Unlike most other drugs under clinical investigation, MDMA has a complex and controversial history that has delayed dispassionate scientific investigation into its therapeutic use.
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Ketamine: A Possible Role for Patients Who Are Running Out of Options?
May 3rd 2011If ketamine is able to turn off a patient’s depression, even for one day, you have accomplished something important, whether or not you can maintain it. This is because you have at least given the patient hope . . . that in itself is very significant from a therapeutic perspective.
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