Jose M. Rubio, MD

Clinicians should keep in mind the risk-to-benefit ratio considerations before initiating polypharmacy, especially if they have patients with prescriptions inherited from several sources. Here: A summary of recommendations about the use of polypharmacy in psychotic disorders.

Which treatments have proven to be efficacious in meta-analyses as augmentation of clozapine in reducing positive symptoms of schizophrenia? The answer might surprise you.

Antipsychotic drugs are the cornerstone in the management of psychotic disorders, but most patients fail to have a “good” response in short-term trials. Alternative strategies are presented here.